PYRIDOPYRAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATING OR PREVENTING PHYSIOLOGICAL AND/OR PATHOPHYSIOLOGICAL CONDITIONS BY INHIBITION OF ENZYMES ERK, ERK1, ERK2, PI3K, PI3Kalpha, PI3Kbeta, PI3Kgamma, PI3Kdelta, PI3K-C2alpha, PI3K-C2beta, PI3K-Vps34p (VERSIONS)

摘要

FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to new pyrido[2,3-b]pyrazine derivatives of general formula(I), wherein radicals and symbols are specified in the patent claim. The given compounds inhibit the enzymes ERK, ERK1, ERK2, PI3K, PI3Kalpha, PI3Kbeta, PI3Kgamma, PI3Kdelta, PI3K-C2alpha, PI3K-C2beta, PI3K-Vps34p.EFFECT: invention refers to a pharmaceutical composition to be used for preparing the drugs applicable first for treating malignant and other diseases implying the pathological cell proliferation.10 cl, 3 tbl, 66 ex