TRANSDERMAL THERAPEUTIC SYSTEM COMPRISING ION PAIR MICRO-RESERVOIRS

摘要

PROBLEM TO BE SOLVED: To provide a transdermal therapeutic system which comprises a supporting layer that is impermeable to an active substance, a peelable protective layer that is impermeable to the active substance, and at least one matrix layer consisting of polysiloxane and/or polysiloxane derivatives and comprising micro-reservoirs.SOLUTION: The micro-reservoirs include at least one ion pair from a pharmacologically active substance and an additive. The active substance is nucleophilic and the additive is electrophilic; or the active substance is electrophilic and the additive is nucleophilic.