发明名称 |
MODIFIED POLYNUCLEOTIDES ENCODING BASIC HELIX-LOOP-HELIX FAMILY, MEMBER E41 |
摘要 |
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules. |
申请公布号 |
US2014199371(A1) |
申请公布日期 |
2014.07.17 |
申请号 |
US201314104531 |
申请日期 |
2013.12.12 |
申请人 |
Moderna Therapeutics, Inc. |
发明人 |
Bancel Stephane;Chakraborty Tirtha;de Fougerolles Antonin;Whoriskey Susan;Weiss Ron |
分类号 |
C12N15/85 |
主分类号 |
C12N15/85 |
代理机构 |
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代理人 |
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主权项 |
1. A method of producing a protein of interest in a cell, tissue or organism comprising contacting said cell, tissue or organism with a nucleic acid encoding SEQ ID NO: 873, wherein said nucleic acid comprises a coding region, said coding region having an altered G/C content as compared to the G/C content of the coding region comprising nucleotides 349-1797 of SEQ ID NO: 258. |
地址 |
Cambridge MA US |