| 发明名称 |
INHIBITORY ANTI-FACTOR XII/XIIA MONOCLONAL ANTIBODIES AND THEIR USES |
| 摘要 |
The invention relates to inhibitory anti-factor XII/FXIIa antibodies and methods of their use. |
| 申请公布号 |
US2014199361(A1) |
申请公布日期 |
2014.07.17 |
| 申请号 |
US201214234021 |
申请日期 |
2012.07.20 |
| 申请人 |
Panousis Con;Rayzman Veronika;Nash Andrew;Wilson Michael;Schmidbauer Stefan;Nolte Marc |
发明人 |
Panousis Con;Rayzman Veronika;Nash Andrew;Wilson Michael;Schmidbauer Stefan;Nolte Marc |
| 分类号 |
C07K16/36 |
主分类号 |
C07K16/36 |
| 代理机构 |
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代理人 |
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| 主权项 |
1. An anti-Factor XII/XIIa monoclonal antibody or antigen-binding fragment thereof that has a more than 2 fold higher binding affinity to human Factor XIIa-beta than to human Factor XII and that is capable of inhibiting the amidolytic activity of human Factor XIIa at a concentration of 100 nM or lower in an in vitro amidolytic activity assay by 80% or more. |
| 地址 |
Melbourne AU |
