| 发明名称 |
COMPOSITIONS AND METHODS FOR DETECTION AND TREATMENT OF CANCER |
| 摘要 |
Novel antibodies for the detection and/or treatment of a cancer (e.g., a pancreatic cancer or an ovarian cancer) are provided. In certain embodiments the antibodies bind a region of the MUC4 protein that does not comprise the central tandem repeat (TR) domain of MUC4. Certain antibodies bind to the MUC4 peptide fragment MUC4-α-N-Ter and/or to the MUC4 peptide fragment MUC4-α-C-Ter. Chimeric constructs comprising such antibodies are also provided. |
| 申请公布号 |
US2014199242(A1) |
申请公布日期 |
2014.07.17 |
| 申请号 |
US201214122171 |
申请日期 |
2012.06.06 |
| 申请人 |
Batra Surinder K.;Jain Maneesh;Ponnusamy Moorthy P. |
发明人 |
Batra Surinder K.;Jain Maneesh;Ponnusamy Moorthy P. |
| 分类号 |
C07K16/30;G01N33/574;A61K49/00 |
主分类号 |
C07K16/30 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated antibody that binds a region of the MUC4 protein that does not comprise the central tandem repeat (TR) domain of MUC4. |
| 地址 |
Omaha NE US |
