TREATMENT OF GRAFT-VERSUS-HOST DISEASE DISORDERS USING RAR ANTAGONISTS

摘要

The present specification provides RAR antagonist compounds, compositions comprising such RAR antagonists, and methods using such compounds and compositions to treat a graft-versus-host disorder, transplant rejection, and inflammation associated with a graft-versus-host disorder or transplant rejection, as well as use of such RAR antagonists to manufacture a medicament and use of such compounds and compositions to treat a graft- versus-host disorder, transplant rejection, and inflammation associated with a graft-versus-host disorder or transplant rejection. Also disclosed are combinations of RAR antagonists and RXR agonists in the disclosed methods and uses.