| 发明名称 |
METHOD FOR PURIFYING ROCURONIUM BROMIDE |
| 摘要 |
Provided is a method for purifying rocuronium bromide, which comprises: formulating crude rocuronium bromide to be purified into an aqueous solution, distilling off excess residue solvents at reduced pressure, absorbing by adding active carbon or silica gel, then filtrating, quick freezing the filtrate into ice, and then lyophilizing to obtain rocuronium bromide. |
| 申请公布号 |
US2014200340(A1) |
申请公布日期 |
2014.07.17 |
| 申请号 |
US201114122679 |
申请日期 |
2011.04.25 |
| 申请人 |
ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. |
发明人 |
Zeng Zhiwen;Wang Peng;Zhang Wenling;Zhang Xini |
| 分类号 |
C07J43/00 |
主分类号 |
C07J43/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for purifying crude rocuronium bromide, characterized in
formulating the crude rocuronium bromide to be purified into a 5˜40 mass % aqueous solution, distilling under reduced pressure, adding active carbon or silica gel in an amount of 1˜5% by mass of the crude rocuronium bromide for adsorption, filtering, and quickly freezing the filtrate into ice, which is then subjected to lyophilization to obtain rocuronium bromide. |
| 地址 |
Zhejiang CN |
