Peptides which are able to enter mammalian cells by translocating into the cell cytosol are disclosed, as well as nucleic acids encoding such peptides. Further, peptides for inhibiting NF-kB, and the nucleic acid encoding these peptides are also described. These peptides are based on the toxin AIP56 found in the Gram-negative bacterium Photobacterium damselae piscicida (Phdp).
申请公布号
WO2014109658(A2)
申请公布日期
2014.07.17
申请号
WO2014PT00001
申请日期
2014.01.09
申请人
INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR
发明人
DOS SANTOS, NUNO;DO VALE, ANA;SILVA, DANIELA;PEREIRA, LILIANA;AZEVEDO, JORGE;PEREIRA, PEDRO;MACEDO-RIBEIRO, SANDRA