GENES INDUCING AGONISTIC EFFECTS BY ANTI-C-MET ANTIBODY TREATMENT AND DRUG SCREENING METHOD USING THE GENES

摘要

Biomarkers for screening drugs reducing side effects of anti-c-Met antibodies and a method of screening using the biomarkers, and more particularly, biomarkers commonly enhancing or reducing gene expression and a method of screening anti-c-Met antibodies having reduced side effects using the biomarkers or a method of screening drugs that reduce side effects of anti-c-Met antibodies.

主权项

1. A DNA microarray chip comprising one or more oligonucleotide sequences selected from the group consisting of:
SPRY4 (GenBank Accession No.: AK226147.1), EGR1 (GenBank Accession No.: BC073983.1), IL8 (GenBank Accession No.: BT007067.1), HBEGF (GenBank Accession No.: AK222688.1), EGR2 (GenBank Accession No.: NM—001136178.1), RHOB (GenBank Accession No.: CX756248), KLF2 (GenBank Accession No.: NM—016270.2), PLK3 (GenBank Accession No.: CR607047.1), SPRR2D (GenBank Accession No.: NM—006945.4), CSF2 (GenBank Accession No.: NM—000758.2), TNFAIP3 (GenBank Accession No.: NM—006290.2), KDM6B (GenBank Accession No.: BU685696), GDF15 (GenBank Accession No.: NM—004864.2), DUSP6 (GenBank Accession No.: BC005047.1), SPRR2E (GenBank Accession No.: NM—001024209.2), DUSP5 (GenBank Accession No.: NM—004419.3), CXCL2 (GenBank Accession No.: AI446767), FOS (GenBank Accession No.: AK298659.1), OVOL1 (GenBank Accession No.: NM—004561.2), MAFF (GenBank Accession No.: NM—012323.2), CLCF1 (GenBank Accession No.: NM—013246.2), ZNF697 (GenBank Accession No.: BM904784), SERTAD1 (GenBank Accession No.: NM—013376.3), LIF (GenBank Accession No.: AI570795), CTGF (GenBank Accession No.: NM—001901.2), EGR4 (GenBank Accession No.: NM—001965.2), TMEM88 (GenBank Accession No.: NM—203411.1), CSRNP1 (GenBank Accession No.: BM129310), ZFP36L1 (GenBank Accession No.: BC018340.1), EPHA2 (GenBank Accession No.: NM—004431.2), PTGER4 (GenBank Accession No.: NM—000958.2), FOSB (GenBank Accession No.: NM—006732.2), ARID3B (GenBank Accession No.: AK298716.1), ANGPTL4 (GenBank Accession No.: NM—139314.1), PHLDA2 (GenBank Accession No.: CB991991), C17orf91 (GenBank Accession No.: NM—001001870.1), BCL2A1 (GenBank Accession No.: NM—001114735.1), CYR61 (GenBank Accession No.: AK295430.1), LOC730755 (GenBank Accession No.: BC063625.1), MFSD2A (GenBank Accession No.: AF370364.1), NR4A1 (GenBank Accession No.: NM—002135.3), PLAUR (GenBank Accession No.: AY029180.1), KRT17 (GenBank Accession No.: g197383031), CDKN1A (GenBank Accession No.: NM—078467.1), CXCL3 (GenBank Accession No.: NM—002090.2), CLN8 (GenBank Accession No.: AF123760.1), SPRR1B (GenBank Accession No.: NM—003125.2), ADM (GenBank Accession No.: BF589790), JUNB (GenBank Accession No.: NM—002229.2), KRT16///KRT16P1///KRT16P2///KRT16P3 (GenBank Accession No.: AK301679.1), GEM (GenBank Accession No.: NM—005261.2), BHLHE40 (GenBank Accession No.: BC082238.1), NR4A3 (GenBank Accession No.: D78579.1), ACSL4 (GenBank Accession No.: AK294197.1), ITPKC (GenBank Accession No.: NM—025194.2), AEN (GenBank Accession No.: AK022624.1), TRAF1 (GenBank Accession No.: BC024145.2), PFKFB2 (GenBank Accession No.: AB044805.1), NIPAL1 (GenBank Accession No.: NM—207330.1), TRIB1 (GenBank Accession No.: NM—025195.2), KBTBD8 (GenBank Accession No.: NM—032505.2), DIDO1 (GenBank Accession No.: BX097024), ZYX (GenBank Accession No.: NM—003461.4), KRT16P1 (GenBank Accession No.: AK301679.1), PHLDA1 (GenBank Accession No.: BC110820.1), KCTD11 (GenBank Accession No.: NM—001002914.2), IER3 (GenBank Accession No.: NM—003897.3), G0S2 (GenBank Accession No.: BE874862), FOSL1 (GenBank Accession No.: NM—005438.3), CD274 (GenBank Accession No.: AK300470.1), DUSP2 (GenBank Accession No.: NM—004418.3), MCL1 (GenBank Accession No.: BC107735.1), ARC (GenBank Accession No.: NM—015193.3), ATF3 (GenBank Accession No.: NM—001040619.1), JUN (GenBank Accession No.: BG491844), MFNG (GenBank Accession No.: NM—002405.2), CCRN4L (GenBank Accession No.: BC023512.2), EREG (GenBank Accession No.: BC136404.1), CXCL1 (GenBank Accession No.: NM—001511.1), TP53RK (GenBank Accession No.: AB065434.1), METRNL (GenBank Accession No.: BC118558.1), SERTAD2 (GenBank Accession No.: BC101639.1), FLJ36031 (GenBank Accession No.: BC013906.2), PTX3 (GenBank Accession No.: BC039733.1), DOT1L (GenBank Accession No.: AF509504.1), CCL20 (GenBank Accession No.: NM—004591.2), CD83 (GenBank Accession No.: AK290426.1), AMOTL2 (GenBank Accession No.: CN364627), JMJD6 (GenBank Accession No.: CR602714.1), ZBTB24 (GenBank Accession No.: BC036731.1), MCPH1 (GenBank Accession No.: BC030702.1), HNRNPC (GenBank Accession No.: AK302213.1), NCOA7 (GenBank Accession No.: BQ003857), SOCS4 (GenBank Accession No.: AF424815.1), DUSP1 (GenBank Accession No.: AK299391.1), CDC42EP2 (GenBank Accession No.: AF098290.1), YRDC (GenBank Accession No.: NM—024640.3), PRSS22 (GenBank Accession No.: BX356243), MARS2 (GenBank Accession No.: NM—138395.2), SPRR2A (GenBank Accession No.: NM—005988.2), SLC25A25 (GenBank Accession No.: NM—052901.2), PTGS2 (GenBank Accession No.: BC013734.1), TICAM1 (GenBank Accession No.: NM—182919.2), RPS27A (GenBank Accession No.: BC042362.1), SPRR2F(GenBank Accession No.: NM—001014450.1), ITPRIP(GenBank Accession No.: NM—033397.2), DCUN1D3 (GenBank Accession No.: NM—173475.2), SPOCD1 (GenBank Accession No.: NM—144569.4), SAMD4A (GenBank Accession No.: AF429970.1), RRAD (GenBank Accession No.: NM—001128850.1), C6orf141 (GenBank Accession No.: NM—001145652.1), LAMB3 (GenBank Accession No.: AK296851.1), IL1RL1 (GenBank Accession No.: AK303389.1), SEMA7A (GenBank Accession No.: AK293280.1), ZNF562 (GenBank Accession No.: AK304370.1), C8orf4 (GenBank Accession No.: AA702805), MAP3K14 (GenBank Accession No.: NM—003954.2), SOCS3 (GenBank Accession No.: NM—003955.3), BMP2 (GenBank Accession No.: M22489.1), ZNF451 (GenBank Accession No.: BC021712.2), LOC643008 (GenBank Accession No.: AK055768.1), CDKN1B (GenBank Accession No.: NM—004064.3), ALPP (GenBank Accession No.: NM—001632.3), NHLRC1 (GenBank Accession No.: NM—198586.2), ZNF624 (GenBank Accession No.: NM—020787.2), KBTBD7 (GenBank Accession No.: AK299614.1), LOC100506379 (GenBank Accession No.: CR622974.1), LIPT2(GenBank Accession No.: NM—001144869.1), BMF (GenBank Accession No.: NM—033503.3), ZBED2 (GenBank Accession No.: NM—024508.3), and SOX2 (GenBank Accession No.: NM—003106.2), or portion thereof or sequence complementary thereto.