Interferon Alpha Antibodies And Their Uses

摘要

The present invention provides isolated anti-interferon alpha monoclonal antibodies, particularly human monoclonal antibodies, that inhibit the biological activity of multiple interferon (IFN) alpha subtypes but do not substantially inhibit the biological activity of IFN alpha 21 or the biological activity of either IFN beta or IFN omega. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the biological activity of IFN alpha using the antibodies of the invention, as well as methods of treating disease or disorders mediated by IFN alpha, such as autoimmune diseases, transplant rejection and graft versus host disease, by administering the antibodies of the invention.

主权项

1. An isolated anti-interferon alpha monoclonal antibody, or antigen binding portion thereof, comprising a heavy chain variable region comprising CDR1, CDR2, and CDR3 domains and a light chain variable region comprising CDR1, CDR2, and CDR3 domains, wherein: (a) the heavy chain variable region CDR3 domain comprises an amino acid sequence selected from the group consisting of amino acid sequences of SEQ ID NOs: 7, 8 and 9, and conservative modifications thereof; and (b) the light chain variable region CDR3 domain comprises an amino acid sequence selected from the group consisting of amino acid sequence of SEQ ID NOs: 16, 17 and 18, and conservative modifications thereof.