发明名称 |
METHOD FOR IN VITRO DETECTION AND MONITORING OF A DISEASE BY MEASURING DISEASE-ASSOCIATED PROTEASE ACTIVITY IN EXTRACELLULAR VESICLES |
摘要 |
The present invention relates to a method for in vitro detection and/or monitoring of a disease in a sample, based on measurement of enzymatic activity of proteases activated and secreted upon disease development, to modified peptides used for the enzymatic detection of the proteases, the use of the peptides, a kit comprising such peptides and the use of ADAM-protease activity as a surrogate marker for disease burden and activity in infectious, inflammatory, and malignant diseases, such as HIV infection and melanoma. |
申请公布号 |
WO2014108480(A1) |
申请公布日期 |
2014.07.17 |
申请号 |
WO2014EP50335 |
申请日期 |
2014.01.09 |
申请人 |
FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG |
发明人 |
BAUR, ANDREAS;SAKSELA, KALLE;SCHULER, GEROLD |
分类号 |
C12Q1/37;G01N33/542;G01N33/569;G01N33/574;G01N33/68 |
主分类号 |
C12Q1/37 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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