| 摘要 |
PURPOSE: A composite is provided to effectively lower blood fats, to enhance lipoprotein cholesterol concentration, and to prevent and treat vascular diseases and atherosclerosis. CONSTITUTION: A composite which lowers blood fats and enhances high density lipoprotein cholesterol contains monascin which is prepared by extracting from a fermented Monascus product. A method for preparing the composite comprises: a step of extracting the fermented Monascus product using acetone three times(102); a step of concentrating the extract by decompression to enhance extract concentration(103); and a step of isolating the extract by silica gel, column chromatography, silica gel, or high performance liquid chromatography and obtaining monascin and ankaflavin(104,105,106,107). [Reference numerals] (101) Providing a fermented Monascus product; (102) Repeatedly extracting the fermented Monascus product using acetone three times; (103) Increasing the concentration of the product obtained from the previous step by decompression concentration in a predetermined temperature range; (104) Isolating a pigment isolating solution by implementing a first isolating and purifying process for the product obtained from the previous step with silica gel column chromatography; (105) Isolating a yellow pigment isolating solution by implementing a second isolating and purifying process for the pigment isolating solution obtained from the previous step with Sephadex LH-20 column chromatography; (106) Isolating an isolating solution containing monascin and ankaflavin by implementing a third purifying process for the yellow pigment isolating solution obtained from the previous step with silica gel column chromatography; (107) Isolating monascin components by implementing a fourth purifying process for the isolating solution containing monascin and ankaflavin obtained from the previous step with preparative high performance liquid chromatography; (AA) Start; (BB) End |
