发明名称 |
c-MET KINASE INHIBITORS FOR TREATING PROLIFERATIVE DISEASE |
摘要 |
<p>PROBLEM TO BE SOLVED: To provide compounds useful as inhibitors of protein kinases.SOLUTION: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides processes for preparing the compounds of the invention, pharmaceutically acceptable compositions comprising the compounds of the invention, and methods of using the compositions in the treatment of various disorders. Specifically, the invention provides pharmaceutical compositions that include a compound of formula I and a pharmaceutically acceptable carrier, adjuvant, or vehicle. In addition, the invention provides methods of treating or lessening the severity of a proliferative disease, condition, or disorder in a patient.</p> |
申请公布号 |
JP2014132024(A) |
申请公布日期 |
2014.07.17 |
申请号 |
JP20140054013 |
申请日期 |
2014.03.17 |
申请人 |
VERTEX PHARMACEUTICALS INC |
发明人 |
LAUFFER DAVID J;ROBERT J DAVIES;STAMOS DEAN;ALEXANDER ARONOV;DAVID D DEININGER;RONALD GERY JR;XU JINWANG;LI PAN;LEDFORD BRIAN;FARMER LUC;RANDY SCOTT BETHIEL;DYLAN JACOBS;KIRA MCGINTY |
分类号 |
C07D401/04;A61K31/4365;A61K31/437;A61K31/439;A61K31/4439;A61K31/444;A61K31/4545;A61K31/46;A61K31/4709;A61K31/4725;A61K31/496;A61K31/497;A61K31/498;A61K31/501;A61K31/504;A61K31/536;A61K31/537;A61K31/5377;A61K31/55;A61K45/00;A61P7/00;A61P9/10;A61P11/00;A61P35/00;A61P35/02;A61P35/04;A61P37/06;A61P37/08;A61P43/00;C07D401/10;C07D403/04;C07D405/14;C07D409/04;C07D409/14;C07D413/10;C07D417/14;C07D451/04;C07D471/04;C07D471/08;C07D487/08;C07D491/08;C07D495/04;C07D513/04 |
主分类号 |
C07D401/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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