Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation
摘要
Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.
申请公布号
AU2012362236(A1)
申请公布日期
2014.07.17
申请号
AU20120362236
申请日期
2012.12.28
申请人
CYTOKINETICS, INC.;GLOBAL BLOOD THERAPEUTICS, INC.;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人
METCALF, BRIAN;CHUANG, CHIHYUAN;WARRINGTON, JEFFREY;PAULVANNAN, KUMAR;JACOBSON, MATTHEW P.;HUA, LAN;MORGAN, BRADLEY