BIFUNCTIONAL PHOSPHONATE CHELATING AGENTS

摘要

Compounds of the following Formula (I):;in whichA represents either a nitrogen atom, or a ring having 3 to 6 carbon atoms, or an aromatic ring having 5 to 10 members, the ring and the aromatic ring optionally include one or more heteroatoms selected from N, O and S, and W represents a grafting function and X and Y represent chelating functions.

主权项

1. Compounds of the following Formula (I): in which A represents
either a nitrogen atom,or a ring comprising from 3 to 6 carbon atoms, or an aromatic ring comprising from 5 to 10 members, said ring and said aromatic ring optionally comprising one or more heteroatoms selected from N, O and S, W represents
either a bromine atom, or an iodine atom,or an E-G-Q group with
E selected from the group consisting of an oxygen atom, a —C≡C— group, a (CH2)m group, m being an integer comprised between 0 and 5, and a —CONH— group,G is selected from the group consisting of
i) —(CH2)o, o being an integer comprised between 0 and 5,ii) —(CH2)n—NH—, n being an integer comprised between 0 and 5,iii) —(CH2)p-CO—NH—(CH2)q-NH—, p and q being integers comprised between 0 and 5, andiv) r, s and t being, each independently of one another, an integer comprised between 0 and 5, and R2 and R3 representing, each independently of one another, a hydrogen atom, a (C1-C4)alkyl group or a hydrolyzable groupQ represents either a hydrogen atom, or an amine protecting group, or a functional group capable of forming a covalent bond with the primary and secondary amines, alcohols and thiols and X and Y represent, independently of one another,
either a hydrogen atom,or a group, where u is an integer equal to 0 or 1, v and w, identical or different, are integers equal to 1 or 2, R2 and R3 represent, each independently of one another, a hydrogen atom, a (C1-C4)alkyl group or a hydrolyzable group selected from the group consisting of the esters and the amides and J is either —CH2, or is an aromatic ring comprising from 5 to 10 members and optionally one or more heteroatoms selected from N, O and S,
or a group, where r1, s1 and t1 are, each independently of one another, an integer comprised between 1 and 2, and R2 and R3 represent, each independently of one another, a hydrogen atom, a (C1-C4)alkyl group or a hydrolyzable group selected from the group consisting of the esters and the amides, provided that X, W and Y are not simultaneously H, and salts thereof.