发明名称 |
PYRIDO- OR PYRROLO-FUSED PYRIMIDINE DERIVATIVES AS AUTOTAXIN INHIBITORS FOR TREATING PAIN |
摘要 |
The present invention provides compounds of the Formula I: [Formula should be inserted here] wherein X is a bond or CH2; R is selected from the group consisting of [Formula should be inserted here] R1 and R2 are each independently selected from the group consisting of CH and N; R3 is H or CH3; R4 is H or CH3; L is selected from the group consisting of -0(CH2)3-, -C(0)NH(CH2)2-, -CH2C(0)NH(CH2)2-, -(CH2)3N(C(0)CH3)CH2-, -(CH2)2N(C(0)CH3)CH2-, -(CH2)3NH-, (CH2)2OCH2-, -(CH2)4-, -(CH2)2NHCH2-, -(CH2)30-, and -CH20(CH2)2-; pharmaceutically acceptable salt thereof. Compounds of this invention are autotaxin inhibitors. |
申请公布号 |
WO2014110000(A1) |
申请公布日期 |
2014.07.17 |
申请号 |
WO2014US10400 |
申请日期 |
2014.01.07 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
BEAUCHAMP, THOMAS, JAMES;DAO, YEN;JONES, SPENCER, BRIAN;NORMAN, BRYAN, HURST;PFEIFER, LANCE, ALLEN |
分类号 |
C07D487/04;A61K31/5025;A61P29/00;C07D471/04 |
主分类号 |
C07D487/04 |
代理机构 |
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