发明名称 |
Compositions and methods for inhibiting expressions of IKK-B gene |
摘要 |
<p>The present invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a human IKK-B gene in a cell, wherein said dsRNA comprises at least two sequences that are complementary to each other and wherein a sense strand comprises a first sequence and an antisense strand comprises a second sequence comprising a region of complementarity which is substantially complementary to at least a part of a mRNA encoding IKK-B, and wherein said region of complementarity is less than 30 nucleotides in length and wherein said dsRNA, upon contact with a cell expressing said IKK-B, inhibits expression of said IKK-B gene by at least 25%, wherein (a) said first sequence is the sequence of SEQ ID NO: 29 and said second sequence is the sequence of SEQ ID NO: 30; or (b) said first sequence is the sequence of SEQ ID NO: 23 and said second sequence is the sequence of SEQ ID NO: 24.</p> |
申请公布号 |
EP2584051(B1) |
申请公布日期 |
2014.07.16 |
申请号 |
EP20120189641 |
申请日期 |
2007.05.21 |
申请人 |
ALNYLAM PHARMACEUTICALS INC.;IMPERIAL INNOVATIONS LTD |
发明人 |
FOUGEROLLES, ANTONIN DE;SPRAGUE, ANDREW;HARBORTH, JENS;BELVISI, MARIA GABRIELA;BIRRELL, MARK ANDREW;HARDAKER, ELIZABETH LOUISE;CATLEY, MATTHEW COPELAND |
分类号 |
C12Q1/70;C12N15/113;C12N15/86 |
主分类号 |
C12Q1/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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