Antifungal compounds, compositions and uses thereof

摘要

The present invention relates to a novel broad-spectrum antifungal compound 5 and a broad-spectrum antifungal composition, comprising 3 methyl -1 [[6 - (1H – pyrrol- yl ) -2- methanesulfonyl -1 - phenyl] benzothiazole] -1H – pyrrole -2 — ol. The compound or composition can be used in the preparation of broad-spectrum antifungal agents for the treatment of severe invasive aspergillosis infection and I or invasive candidiasis caused by fluconazole-resistant Candida (including Candida krusei) and / or severe infections of the foot caused by actinomycetes bacteria and Fusarium. The compounds and compositions described have a wide range of powerful anti-fungal activity, pharmacokinetic properties and low toxicity.