发明名称 |
CHIRAL COMPOUNDS OF VARYING CONFORMATIONAL RIGIDITY AND METHODS OF SYNTHESIS |
摘要 |
Synthesis of compounds having varying degrees of conformational rigidity is obtained via a low cost, high yield and efficient synthetic reactions. The library of compounds is structurally diverse having at least one or more chiral centers and providing large numbers of compounds having building block diversity and substantial scaffold diversity. The compounds further provide a novel method for obtaining candidate therapeutic agents for prevention, treatment or diagnosis of diseases. |
申请公布号 |
EP2753175(A1) |
申请公布日期 |
2014.07.16 |
申请号 |
EP20120829942 |
申请日期 |
2012.09.07 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
MICALIZIO, GLENN, C.;KODADEK, THOMAS;SARKAR, MOHOSIN |
分类号 |
A01N37/00;A61K31/19;A61K38/06;A61K45/06;C07B53/00;C07C51/00;C07C57/52;C07C57/54;C07C57/60;C07C57/64;C07D405/14;C07K5/02;C07K5/08;C07K5/083;G01N33/50 |
主分类号 |
A01N37/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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