CHARACTERIZATION OF CHO-MIF GENE AND PROTEIN, AND USE THEREOF
摘要
The present invention is concerned with the specific and highly sensitive detection of specific CHO-MIF (macrophage migration inhibitory factor from Chinese Ovarian Hamster cell line) complexes in the production of anti-MIF antibodies. The present invention is further concerned with the provision of specific antibodies which can be used for a CHO-MIF detection method. The present invention is also concerned with a CHO MIF knockout cell line and use thereof. The present invention also provides preparations obtained from recombinant production in CHO cell lines which are essentially free of CHO-MIF.
申请公布号
EP2753937(A1)
申请公布日期
2014.07.16
申请号
EP20120770473
申请日期
2012.10.04
申请人
BAXTER HEALTHCARE SA;BAXTER INTERNATIONAL INC
发明人
KERSCHBAUMER, RANDOLF, J.;VOELKEL, DIRK;ANTOINE, GERHARD;SCHEIFLINGER, FRIEDRICH;MUDDE, C. GEERT