发明名称 |
FINE STRUCTURE DETERMINATION METHOD OF ENOXAPARIN SODIUM BASED ON CAPILLARY ELECTROPHORESIS |
摘要 |
<p>A capillary electrophoresis method for quantitatively analyzing characteristic oligosaccharide present in enoxaparin sodium is provided in this invention. The method may be used for quantitatively determining the contents of disaccharides, trisaccharides, tetrasaccharides and in particular oligosaccharides having a 1,6-anhydro ring, which are unique compounds for enoxaparin sodium, within an exhaustively digested enoxaparin sodium sample with a mixture of heparinase I, II, and III, so as to quantitatively determine the molar percentage of oligosaccharides having 1,6-anhydro ring in enoxaparin sodium. The method may be used for the pharmaceutical quality control of enoxaparin sodium during the manufacturing process.</p> |
申请公布号 |
EP2667186(A4) |
申请公布日期 |
2014.07.16 |
申请号 |
EP20120739381 |
申请日期 |
2012.01.20 |
申请人 |
HANGZHOU JIUYUAN GENE ENGINEERING CO., LTD.;SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES |
发明人 |
KANG, JINGWU;ZHAN, XUEQIANG |
分类号 |
G01N27/447;A61K31/727;C08B37/00;C08B37/08;C08B37/10;G01N33/15 |
主分类号 |
G01N27/447 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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