发明名称 |
METHOD FOR IMPROVING DISSOLVABILITY OF ANTICOAGULANT |
摘要 |
It is desired to provide a pharmaceutical composition containing a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, or a solvate thereof, which exhibits an inhibitory effect on activated blood coagulation factor X, and is useful as an agent for preventing and/or treating thrombosis, wherein the pharmaceutical composition exhibits favorable dissolution properties. The present invention provides a method for producing a pharmaceutical composition containing a compound represented by formula (I), comprising the step of mixing a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, or a solvate thereof, one or more excipients selected from the group consisting of a sugar alcohol and a water-swelling additive, a disintegrant, and a binder under conditions for keeping the maximum water content of the granules during granulation at 10% or less. |
申请公布号 |
EP2548556(A4) |
申请公布日期 |
2014.07.16 |
申请号 |
EP20110756252 |
申请日期 |
2011.03.14 |
申请人 |
DAIICHI SANKYO COMPANY, LIMITED |
发明人 |
KAMADA, MAKOTO;SEKIGUCHI, GAKU;KIDOKORO, MOTONORI |
分类号 |
A61K31/444;A61K9/16;A61K9/20;A61K9/32;A61K9/36;A61K47/10;A61K47/32;A61K47/36;A61K47/38;A61P7/02 |
主分类号 |
A61K31/444 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|