发明名称 |
METAL COMPLEXES INCORPORATED WITHIN BIODEGRADABLE NANOPARTICLES AND THEIR USE |
摘要 |
<p>The invention is directed to providing a compound for treating cancer, the compound comprising a metal complex having predetermined characteristics, and which may be incorporated into a polymeric nanoparticle or other delivery system for delivering the metal complex for action on tumor cells. The metal complex for treating cancer wherein the metal complex is a silver(I) salt, a silver(I) macrocyclic metal complex, a silver(I) N-heterocyclic carbene or mixtures thereof. The invention is also directed to a silver(I) macrocyclic metal complex and a silver(I) N-heterocyclic carbine, and methods of treating cancerous cells in a mammal including the steps of administering an effective amount of a silver(I) metal salt, such as by incorporating the material into a biodegradable polymeric nanoparticle.</p> |
申请公布号 |
EP2167097(B1) |
申请公布日期 |
2014.07.16 |
申请号 |
EP20080756405 |
申请日期 |
2008.05.29 |
申请人 |
THE UNIVERSITY OF AKRON |
发明人 |
YOUNGS, WILEY, J.;HINDI, KHADIJAH;MEDVETZ, DOUGLAS, A. |
分类号 |
A61K31/555;A61K31/28;A61P31/00;C07F1/00;C07F1/08 |
主分类号 |
A61K31/555 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|