发明名称 |
3-amino-pyrazole derivatives useful against tuberculosis |
摘要 |
A compound of Formula (I) or a pharmaceutically acceptable salt thereof:;
Wherein: Het is a 5 to 10-membered heteroaromatic ring; Either X is N and Y is CR5; or X is C and Y is S; Z is selected from N and CH; R1 is selected from H and C1-2alkyl; R2 is selected from H, C1-2alkyl, OH, —CH2OH and C1-2alkoxy; Each R3 is independently selected from OH, C1-3alkyl, F, Cl, Br, NH2, and C1-3alkoxy; R4 is selected from C1-3alkyl and haloC1-3alkyl; R5 is selected from H, C1-3alkyl and haloC1-3alkyl; R6 and R7 are either i) each independently selected from H, C1-3alkyl and C1-3alkoxy; or ii) R6 and R7 together with the ring to which they are attached form a 9-membered bicylic ring; p is 0-3; and RA is selected from H and C1-3alkyl, compositions containing them, their use in therapy, for example in the treatment of tuberculosis, and methods for the preparation of such compounds, are provided. |
申请公布号 |
US8779153(B2) |
申请公布日期 |
2014.07.15 |
申请号 |
US201113878889 |
申请日期 |
2011.10.11 |
申请人 |
Glaxo Group Limited |
发明人 |
Castro Pichel Julia;Fernandez Menendez Raquel;Fernandez Velando Esther Pilar;Gonzalez Del Valle Silvia;Mallo-Rubio Araceli |
分类号 |
C07D285/135;C07D277/10;A61K31/44 |
主分类号 |
C07D285/135 |
代理机构 |
|
代理人 |
Brink Robert H. |
主权项 |
1. A compound of Formula (I) or a pharmaceutically acceptable salt thereof: wherein: Het is a 5 to 10-membered heteroaromatic ring; either X is N and Y is CR5; or X is C and Y is S; Z is selected from N and CH; R1 is selected from H and C1-2alkyl, R2 is selected from H, C1-2alkyl, OH, —CH2OH and C1-2alkoxy; each R3 is independently selected from OH, C1-3alkyl, F, Cl, Br, NH2, and C1-3alkoxy; R4 is selected from C1-3alkyl and haloC1-3alkyl; R5 is selected from H, C1-3alkyl and haloC1-3alkyl; R6 and R7 are either (i) each independently selected from H, C1-3alkyl and C1-3alkoxy; or (ii) R6 and R7 together with the ring to which they are attached form a 9-membered bicylic ring; p is 0-3; and RA is selected from H and C1-3alkyl. |
地址 |
Brentford, Middlesex GB |