Benzyl piperidine compound

摘要

Provided is a new serotonin-reuptake inhibitor that exhibits affinity for serotonin-1A receptors. Said serotonin-reuptake inhibitor is a compound represented by formula (1) or a pharmacologically acceptable salt thereof. In the formula, R1 represents a hydrogen atom, a 2-hydroxyethyl group, or a 2-methoxyethyl group. R2 represents one of the following bonded to a methylene group which is bonded to a piperidine ring: a chlorine atom bonded in a p-position; a bromine atom bonded in a p-position; a methyl group bonded in a p-position; a chlorine atom bonded in an m-position; or a bromine atom bonded in an m-position. Either Y1 represents a hydrogen atom and Y2 represents a hydrogen atom or a hydroxyl group, or Y1 and Y2 together represent an oxo group. Z represents a group represented by one of the following formulas: formula (3-1-1), formula (3-1-2), formula (3-2-1), formula (3-2-2), formula (3-3-1), formula (3-3-2), formula (3-4-1), or formula (3-4-2). However, if R1 represents a 2-hydroxyethyl group or a 2-methoxyethyl group and Y1 and Y2 both simultaneously represent hydrogen atoms, then Z represents a group represented by one of the following formulas: formula (3-1-2), formula (3-2-1), formula (3-2-2), formula (3-3-1), formula (3-3-2), formula (3-4-1), or formula (3-4-2).;

主权项

1. A compound represented by a formula (1) or a pharmaceutically acceptable salt thereof:wherein R1 represents a hydrogen atom or a group represented by a formula (2):wherein R3 represents a hydrogen atom or a methyl group;
R2 represents a chlorine atom bonded at the p-position, a bromine atom bonded at the p-position, a methyl group bonded at the p-position, a chlorine atom bonded at the m-position or a bromine atom bonded at the m-position, with respect to a methylene group bonded to a piperidine ring; Y1 represents a hydrogen atom, and Y2 represents a hydrogen atom or a hydroxy group or Y1 and Y2 together represent an oxo group; and Z represents a group represented by a formula (3-1-1), (3-1-2), (3-2-1), (3-2-2), (3-3-1), (3-3-2), (3-4-1) or (3-4-2):wherein when R1 represents a group represented by the formula (2) and each of Y1 and Y2 represents a hydrogen atom, Z represents a group selected from the group consisting of the formulas (3-1-2), (3-2-1), (3-2-2), (3-3-1), (3-3-2), (3-4-1) and (3-4-2).