Phenylpyridine derivative and medicinal agent comprising same

摘要

Disclosed are: a novel compound which has both an antagonistic activity on an angiotensin II receptor and a PPARγ-activating activity and is therefore useful as a prophylactic and/or therapeutic agent for hypertension, heart diseases, arteriosclerosis, type-2 diabetes, diabetic complications, metabolic syndrome or the like; and a pharmaceutical composition containing the compound. Specifically disclosed are: a compound represented by general formula (I) (wherein the ring A represents a pyridine ring; the ring B represents a tetrazole ring or an oxadiazol-5(4H)-one ring; X represents C—R5 or a nitrogen atom; R1 represents a C1-6 alkyl group; R2 represents a C1-6 alkyl group or a C3-8 cycloalkyl group; and R3, R4, R5 independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group, a halo-C1-6 alkyl group, or a C1-6 alkoxy group which may have a substituent), a salt of the compound, or a solvate of the compound or the salt; and a pharmaceutical composition containing the compound, the salt or the solvate.

主权项

1. A compound represented by the formula (I) below or a salt thereof, or a solvate thereof: wherein, in the formula (I), ring A represents the following formula (II) or the following formula (III): wherein, in the formula (I), Ring B represents the following formula (IV) or the following formula (V): wherein X represents C—R5 or a nitrogen atom, wherein R1 represents a C1-6 alkyl group, wherein R2 represents a C1-6 alkyl group or a C3-8 cycloalkyl group, and wherein R3, R4, and R5 represent, independently from each other, a hydrogen atom, a halogen atom, a C1-6 alkyl group, a halo C1-6 alkyl group, or a C1-6 alkoxy group which may have a substituent group, respectively.