CA9 gene single nucleotide polymorphisms predict prognosis and treatment response of metastatic renal cell carcinoma

摘要

Methods and compositions for providing a prognosis or diagnosis for a human patient having renal cell cancer are provided. The method relates to the discovery of SNPs which are associated with a favorable prognosis and response to therapy in RCC.

主权项

1. A method of treating a human patient having metastatic renal cell carcinoma (MRCC), said method comprising:
(a) obtaining a biological sample containing Carbonic Anhydrase 9 (CA9) nucleic acid from the patient; (b) analyzing the biological sample to determine whether the CA9 nucleic acid has a C allele at polymorphic site rs12553173, thereby determining whether the patient has a C allele at polymorphic site rs12553173; (c) determining that the patient has an increased likelihood of responding to an IL-2 immunotherapy when the patient has a C allele at polymorphic site rs12553173; and (d) administering the IL-2 immunotherapy to the patient having the C allele at polymorphic site rs12553173, thereby treating the patient.