Viral inhibitors

摘要

The present invention relates to imidazo[4,5-c]pyridine compounds and pharmaceutical compositions for the treatment or prevention of viral infections, wherein the imidazo[4,5-c]pyridine compounds have the formula:;

主权项

1. A compound selected from the group consisting of
2-(2,6-Difluorophenyl)-5-[(2,6-difluorophenyl)methyl]-5H-imidazo[4,5-c]pyridine; 5-Benzyl-2-(2,6-difluorophenyl)-5H-imidazo[4,5-c]pyridine; 5-[(2,6-Difluorophenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine; 5-Benzyl-2-phenyl-5H-imidazo[4,5-c]pyridine; 2-Phenyl-5-(3-phenylpropyl)-5H-imidazo[4,5-c]pyridine; 5-[(2-Chlorophenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine; 5-[(3-Chlorophenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine; 5-[(4-Chlorophenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine; 5-[(2-Methoxyphenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine; 5-[(3-Methoxyphenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine; 5-[(4-Methoxyphenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine; 5-[(4-Methylphenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine; 5-[(2-Fluorophenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine; 5-[(3-Fluorophenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine; 5-[(4-Fluorophenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine; 5-[(2-Methylphenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine; 5-[(3-Methylphenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine; 5-[(4-Bromophenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine; 4-[(2-Phenyl-5H-imidazo[4,5-c]pyridin-5-yl)methyl ]-benzonitrile; 2-Phenyl-5-[[4-(trifluoromethyl)phenyl]methyl]-5H-imidazo[4,5-c]pyridine; 5-[(4-Chlorophenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine hydrochloride; 5-[(5-Chloro-2-thienyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine; 5-(2-Naphthalenylmethyl)-2-phenyl-5H-imidazo[4,5-c]pyridine; 2-Phenyl-5-(4-phenylbutyl)-5H-imidazo[4,5-c]pyridine; 5-([1,1′-Biphenyl]-4-ylmethyl)-2-phenyl-5H-imidazo[4,5-c]pyridine; 2-Phenyl-5-(1-phenylethyl)-5H-imidazo[4,5-c]pyridine; 5-(1-Naphthalenylmethyl)-2-phenyl-5H-imidazo[4,5-c]pyridine; 2-(2,6-Difluorophenyl)-5-[(2,4-difluorophenyl)methyl]-5H-imidazo[4,5-c]pyridine; 5-[(4-Bromophenyl)methyl]-2-(2-fluorophenyl)-5H-imidazo[4,5-c]pyridine; 5-[(4-Bromophenyl)methyl]-2-(2-chlorophenyl)-5H-imidazo[4,5-c]pyridine; 5-[(4-Bromophenyl)methyl]-2-(3-chlorophenyl)-5H-imidazo[4,5-c]pyridine; 5-[(4-Bromophenyl)methyl]-2-(4-chlorophenyl)-5H-imidazo[4,5-c]pyridine; 5-[(4-Bromophenyl)methyl]-2-(2-pyridinyl)-5H-imidazo[4,5-c]pyridine; 5-[(4-Bromophenyl)methyl]-2-(2-thienyl)-5H-imidazo[4,5-c]pyridine; 5-[(4-Bromophenyl)methyl]-2-(1-naphthalenyl)-5H-imidazo[4,5-c]pyridine; 5-[(4-Bromophenyl)methyl]-2-(2-naphthalenyl)-5H-imidazo[4,5-c]pyridine; 5-[(4-Iodophenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine; 5-[(4-Bromophenyl)methyl]-2-(3-fluorophenyl)-5H-imidazo[4,5-c]pyridine; 5-[(4-Bromophenyl)methyl]-2-(3-methylphenyl)-5H-imidazo[4,5-c]pyridine; 5-[(4-Bromophenyl)methyl]-2-(3-methoxyphenyl)-5H-imidazo[4,5-c]pyridine; 5-[(4-Bromophenyl)methyl]-2-(3-bromophenyl)-5H-imidazo[4,5-c]pyridine; 5-[(4-Chlorophenyl)methyl]-2-(3-bromophenyl)-5H-imidazo[4,5-c]pyridine; 5-[(4-Chlorophenyl)methyl]-2-(3-chlorophenyl)-5H-imidazo[4,5-c]pyridine; 5-(2-Phenoxy-ethyl)-2-phenyl-5H-imidazo[4,5-c]pyridine; 5-(3-Phenyl-prop-2-en-1-yl)-2-phenyl-5H-imidazo[4,5-c]pyridine; 2-(3-Bromophenyl)-5-[(4-iodophenyl)methyl]-5H-imidazo[4,5-c]pyridine; 5-[(4-Bromophenyl)methyl]-2-[(phenylthio)methyl]-5H-imidazo[4,5-c]pyridine; 5-[(4-Bromophenyl)methyl]-2-[3-(trifluoromethyl)phenyl]-5H-imidazo[4,5-c]pyridine; 5-([1,1′-Biphenyl]-4-ylmethyl)-2-(2-fluorophenyl)-5H-imidazo[4,5-c]pyridine; 5-[(4-Chlorophenyl)methyl]-2-(2-fluorophenyl)-5H-imidazo[4,5-c]pyridine; 2-(2-Fluorophenyl)-5-[(4-iodophenyl)methyl]-5H-imidazo[4,5-c]pyridine; 2-phenyl-5-(pyridine-4-ylmethyl)-5H-imidazo[4,5-c]pyridine; 2-phenyl-5-(pyridine-3-ylmethyl)-5H-imidazo[4,5-c]pyridine; 2-phenyl-5-(pyridine-2-ylmethyl)-5H-imidazo[4,5-c]pyridine; and 5[[4-(1,1-Dimethylethyl)phenyl]methyl]-2-(2-fluorophenyl)-5H-imidazo[4,5-c]pyridine; or a stereoisomer thereof or a pharmaceutically acceptable salt thereof.