| 摘要 |
A diazepinedione derivative represented by the formula (I) or a pharmacologically acceptable salt thereof is used as a P2X4 receptor antagonist:;
wherein R1 represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, or the like, R2 and R3 represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a halogen atom, or the like, R4 and R5 represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, or the like, and W represents tetrazole or the like. |
| 主权项 |
1. A method of treating neuropathic pain comprising administering an effective amount of a compound of formula (I) or a pharmacologically acceptable salt thereof to a patient in need thereof:wherein R1 represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, or an alkyl group having 1 to 3 carbon atoms substituted with phenyl;
each of R2 and R3 independently represents a hydrogen atom, a halogen atom, hydroxyl, nitro, cyano, amino, carboxyl, carbamoyl, sulfamoyl, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, an alkoxy group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, an alkylamino group having 1 to 8 carbon atoms, a dialkylamino group having 2 to 8 carbon atoms, an acylamino group having 2 to 8 carbon atoms, an acylamino group having 2 to 8 carbon atoms substituted with 1 to 3 halogen atoms, an alkylsulfonylamino group having 1 to 8 carbon atoms, an acyl group having 2 to 8 carbon atoms, an alkoxycarbonyl group containing an alkoxy moiety having 1 to 8 carbon atoms, an alkylthio group having 1 to 8 carbon atoms, an alkylsulfinyl group having 1 to 8 carbon atoms, or an alkylsulfonyl group having 1 to 8 carbon atoms; each of R4 and R5 independently represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms, or an alkyl group having 1 to 3 carbon atoms substituted with phenyl; and W represents tetrazole, 1,2,4-triazole, 1,2,3-triazole, 1,2,4-oxadiazole, pyrazole, imidazole, oxazole, isoxiazole, pyrrole, thiazole, pyridine, or pyrrolidine, and optionally having a substituent selected from the group consisting of a halogen atom, cyano, oxo, thioxo, an alkyl group having 1 to 8 carbon atom, and an alkyl group having 1 to 8 carbon atoms substituted with 1 to 3 halogen atoms. |
