发明名称 |
BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROMORPHONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF |
摘要 |
The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydromorphone (4,5-α-epoxy-3-hydroxy-17-methyl morphinan-6-one) to form novel prodrugs/compositions of hydromorphone. The hydromorphone prodrugs of the present technology have decreased side effects and decreased potential for abuse compared to unconjugated hydromorphone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology. |
申请公布号 |
KR20140089520(A) |
申请公布日期 |
2014.07.15 |
申请号 |
KR20147010696 |
申请日期 |
2012.10.25 |
申请人 |
KEMPHARM INC. |
发明人 |
MICKLE TRAVIS;GUENTHER SVEN;CHI GUOCHEN;KANSKI JAROSLAW;MARTIN ANDREA K.;BERA BINDU |
分类号 |
A61K47/48;A61K31/485;A61K47/12 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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