| 发明名称 | Cilostazol cocrystals and compositions | ||
| 摘要 | The invention relates to improvements of the physiochemical and/or the pharmaceutical properties of cilostazol. Disclosed herein are several new compositions and cocrystals of cilostazol, including: a 1:1 cilostazol gentisic acid cocrystal, a 1:1:1 cilostazol gentisic acid H2O cocrystal, a 1:1 cilostazol 4-hydroxybenzoic acid cocrystal, and a 1:1 cilostazol 2,4-dihydroxybenzoic acid cocrystal. The therapeutic methods and uses of these cilostazol cocrystals are described as well as therapeutic compositions containing them. | ||
| 申请公布号 | US8779146(B2) | 申请公布日期 | 2014.07.15 |
| 申请号 | US201113643213 | 申请日期 | 2011.04.28 |
| 申请人 | Nuformix Limited | 发明人 | Chorlton Alan;Frampton Christopher;Gooding Daniel;Holland Joanne |
| 分类号 | A61K31/04;C07D215/04;C07D215/20;A61K31/4709 | 主分类号 | A61K31/04 |
| 代理机构 | J.A. Lindeman & Co., PLLC | 代理人 | J.A. Lindeman & Co., PLLC |
| 主权项 | 1. A cilostazol cocrystal selected from a 1:1 cilostazol gentisic acid cocrystal, a 1:1:1 cilostazol gentisic acid H2O cocrystal, a 1:1 cilostazol 4-hydroxybenzoic acid cocrystal, and a 1:1 cilostazol 2,4-dihydroxybenzoic acid cocrystal. | ||
| 地址 | GB | ||