Process for the synthesis of 3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid

摘要

Process for the synthesis of the compound of formula (I):;
Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.

主权项

1. A process for the synthesis of a compound of formula (I):wherein a compound of formula (VIII):is subjected to the action of N-bromosuccinimide in the presence of an organic solvent to yield the compound of formula (I).