Humanized anti-beta7 antagonists and uses therefor

摘要

The invention provides therapeutic anti-beta7 antibodies, compositions comprising, and methods of using these antibodies.

主权项

1. An anti-beta7 antibody comprising:
an HVR-L1, HVR-L2, HVR-L3, HVR-H1, HVR-H2 and HVR-H3, wherein each, in order, comprises RASESVDDLLH (SEQ ID NO:9), KYASQSIS (SEQ ID NO:2), QQGNSLPNT (SEQ ID NO:3), GFFITNNYWG (SEQ ID NO:4), GYISYSGSTSYNPSLKS (SEQ ID NO:5), and ARTGSSGYFDF (SEQ ID NO:64).