B7-H3L cell surface antigen and antibodies that bind thereto

摘要

The invention provides the identification and characterization of disease and cancer-associated antigen, RAAG10. The invention also provides a family of monoclonal antibodies that bind to antigen RAAG10, methods of diagnosing and treating various human cancers and diseases that express RAAG10.

主权项

1. A substantially purified immunoglobulin polypeptide or an antigen binding fragment thereof, that specifically binds to an epitope of a B7-H3L protein that is expressed and exposed in its native conformation on the surface of a living cancer cell in vitro or in vivo, wherein said epitope is insufficiently expressed on the surface of a living normal cell to exhibit binding by said purified immunoglobulin polypeptide, and wherein said purified immunoglobulin polypeptide or antigen binding fragment thereof can be internalized into said cancer cell expressing B7-H3L.