| 主权项 |
1. A compound of the formula: or a pharmaceutically acceptable salt thereof, wherein: A1 is CR6; A2 is N; A3 is CR8; A4 is NR9 or O; L is selected from optionally substituted C1-4alkyl, C3-6 cycloalkyl, C3-6 heterocycloalkyl, or C2-4 alkenyl; R1 is X—R16; X is a bond or C1-4 alkyl; R16 is selected from the group consisting of C1-6 alkyl, C3-6branched alkyl, C3-8cycloalkyl, heterocycloalkyl, C3-8-partially unsaturated cycloalkyl, aryl, and heteroaryl; wherein R16 is substituted with one to three groups independently selected from halogen, hydrogen, C1-6alkyl, C1-6haloalkyl, C3-6branched alkyl, C3-6branched haloalkyl, OH, C1-6alkoxy, R22—OR12, S(O)0-2R12, R22-S(O)0-2R12, S(O)2NR13R14, R22-S(O)2NR13R14, C(O)OR12, R22-C(O)OR12, C(O)R19, R22-C(O)R19, O-C1-3 alkyl, OC1-3 haloalkyl, OC(O)R19, R22-OC(O)R19, C(O)NR13R14, R22—C(O)NR13R14, NR15S(O)2R12, R22—NR15S(O)2R12, NR17R18, R22—NR17R18, NR15C(O)R19, R22—NR15C(O)R19, NR15C(O)OCH2Ph, R22—NR15C(O)OCH2Ph, NR15C(O)OR12, R22—NR15C(O)OR12, NR15C(O)NR13R14, and R22-NR15C(O)NR13R14; R17 and R18 are each, independently, selected from the group consisting of hydrogen, hydroxyl, C1-6alkyl, C1-6haloalkyl, C3-6branched alkyl, C3-6 cycloalkyl, R22—OR12, R22—S(O)0-2R12, R22-S(O)2NR13R14, R22-C(O)OR12, R22-C(O)R19, R22-OC(O)R19, R22-C(O)NR13R14, R22-NR15S(O)2R12, R22-NR23R24, R22-NR15C(O)R19, R22-NR15C(O)OCH2Ph, R22-NR15C(O)OR12, R22-NR15C(O)NR13R14, cycloalkyl, heterocycloalkyl and heteroaryl; alternatively, R17 and R18 along with the nitrogen atom to which they are attached to can be taken together to form a four to six membered heterocyclic ring wherein the carbon atoms of said ring are optionally substituted with R20, and the nitrogen atoms of said ring are optionally substituted with R21; R19 is selected from optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl; R20 is selected from the group consisting of C1-6 alkyl or C1-6 haloalkyl; R21 is selected from the group consisting of C1-6alkyl, C1-6haloalkyl, C(O)R12, C(O)OR12, S(O)2R12; R22 is selected from the group consisting of C1-6 alkyl, C1-6haloalkyl, C3-6 branched alkyl, C3-6branched haloalkyl; R23 and R24 are each, independently, selected from the group consisting of hydrogen, C1-6 alkyl, C1-6haloalkyl, C3-6 branched alkyl, C3-6 branched haloalkyl; R2 is selected from the group consisting of optionally substituted C1-6 alkyl, optionally substituted C3-6 branched alkyl, optionally substituted C3-8 cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl; R4, R5, and R6 are each, independently, selected from the group consisting of hydrogen, hydroxyl, cyano, halogen, C1-4 alkyl, C1-4haloalkyl, C2-4 alkenyl, C2-4 alkynyl, amino, NR10R11, and alkoxy; R3 and R7 are each, independently, selected from the group consisting of hydrogen, hydroxyl, cyano, halogen, alkyl, haloalkyl, alkenyl, alkynyl, alkoxy, NR10R11, C(O)R12, C(O)OR12, C(O)NR13R14, S(O)0-2R12, S(O)0-2NR13R14, and optionally substituted C3-4 cycloalkyl; R8 is selected from Cl, F, and methyl; R9 is selected from the group consisting of hydrogen, C1-4 alkyl, alkoxy, C(O)R12, C(O)OR15, C(O)NR13R14, S(O)0-2R12, S(O)0-2NR13R14, optionally substituted C3-4 cycloalkyl, and optionally substituted heterocycloalkyl; R10 and R11 are each, independently, selected from the group consisting of hydrogen, hydroxyl, alkyl, alkoxy, C(O)R12, C(O)OR12, C(O)NR13R14, S(O)0-2R12, and S(O)0-2NR13R14; alternatively, R10 and R11 along with the nitrogen atom to which they are attached to can be taken together to form an optionally substituted four to six membered heteroaromatic, or a non-aromatic heterocyclic ring; R12 and R15 are each, individually, selected from the group consisting of hydrogen, alkyl, branched alkyl, haloalkyl, branched haloalkyl, (CH2)0-3-cycloalkyl, (CH2)0-3-heterocycloalkyl, (CH2)0-3-aryl, and heteroaryl; R13 and R14 are each, independently, selected from the group consisting of hydrogen, hydroxyl, alkyl, branched alkyl, haloalkyl, branched haloalkyl, alkoxy, cycloalkyl or heterocycloalkyl; and alternatively, R13 and R14 along with the nitrogen atom to which they are attached to can be taken together to form an optionally substituted four to six membered heteroaromatic, or non-aromatic heterocyclic ring. |
