Targeted binding agents against B7-H1

摘要

Human monoclonal antibodies directed against B7-H1 and uses of these antibodies in diagnostics and for the treatment of diseases associated with the activity and/or expression of B7-H1 are disclosed. Additionally, hybridomas or other cell lines expressing such antibodies are disclosed.

主权项

1. An antibody or fragment thereof wherein the antibody binds to the same epitope on the extracellular domain of human B7-H1 as any one of an antibody comprising:
(a) a heavy chain variable domain amino acid sequence encoded by a polynucleotide in a plasmid designated 2.7A4_G which was deposited at the National Collections of Industrial and Marine Bacteria (NCIMB) under deposit number 41598 and a light chain variable domain amino acid sequence encoded by the polynucleotide in a plasmid designated 2.7A4_G which was deposited at the NCIMB under deposit number 41598; or (b) a heavy chain variable domain amino acid sequence encoded by a polynucleotide in a plasmid designated 2.14H9_G which was deposited at the NCIMB under deposit number 41597 and a light chain variable domain amino acid sequence encoded by the polynucleotide in a plasmid designated 2.14H9_G which was deposited at the NCIMB under deposit number 41597; or (c) a heavy chain variable domain amino acid sequence encoded by a polynucleotide in a plasmid designated 2.9D10_NG which was deposited at the NCIMB under deposit number 41599 and a light chain variable domain amino acid sequence encoded by the polynucleotide in a plasmid designated 2.9D10_NG which was deposited at the NCIMB under deposit number 41599.