| 发明名称 |
Pharmaceutical delivery systems for hydrophobic drugs and compositions comprising same |
| 摘要 |
A drug delivery system for oral administration of hydrophobic drugs with enhanced and extended absorption and improved pharmacokinetics is provided. In one embodiment, formulations comprising testosterone and testosterone esters, e.g., testosterone palmitate, are disclosed. Methods of treating a hormone deficiency or effecting male contraception with the inventive formulations are also provided. |
| 申请公布号 |
US8778917(B2) |
申请公布日期 |
2014.07.15 |
| 申请号 |
US201314026655 |
申请日期 |
2013.09.13 |
| 申请人 |
Clarus Therapeutics, Inc. |
发明人 |
Dudley Robert E.;Constantinides Panayiotis P. |
| 分类号 |
A61K31/568;A61K9/48;A61K31/573;A61K31/22;A61K9/107 |
主分类号 |
A61K31/568 |
| 代理机构 |
|
代理人 |
Bennett Dennis A.;Levin Brock |
| 主权项 |
1. An oral pharmaceutical composition consisting essentially of 20% testosterone ester, 39.99% polyoxyethylated apricot kernel oil (Labrafil M1944CS); 13.32% glyceryl palmitostearate (Precirol ATO5) and 26.68% polyoxyethylene (40) hydrogenated castor oil (Cremophor RH40). |
| 地址 |
Northbrook IL US |
