发明名称 |
INHIBIDOR DE LA PRODUCCION DE ENDOGLINA SOLUBLE Y SU APLICACION EN PATOLOGIAS DONDE LA ENDOGLINA SOLUBLE TIENE UN EFECTO PATOGENICO |
摘要 |
The invention relates to an isolated peptide derived from endoglin, characterised in that the amino acid sequence thereof comprises a cleavage site GL for extracellular matrix metalloproteinase 14 (MMP-14 or MT1- MMP), and in that it can block the proteolytic cleavage of the endoglin using MMP-14. The invention also relates to a pharmaceutical composition characterised in that it comprises, by way of active ingredient, at least one endoglin-derived peptide as defined above. The invention further relates to the use of at least one of said endoglin-derived peptides or a pharmaceutical composition as defined above for the treatment of a disorder or disease associated with soluble endoglin (sEng) or with MMP-14. |
申请公布号 |
ES2423382(B1) |
申请公布日期 |
2014.07.15 |
申请号 |
ES20120030244 |
申请日期 |
2012.02.16 |
申请人 |
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC);UNIVERSIDAD DE SALAMANCA;CENTRO DE INVESTIGACION BIOMEDICA EN RED EN ENFERMEDADES RARAS (CIBERER) |
发明人 |
BERNABEU QUIRANTE, CARMELO;VALBUENA DIEZ, ANA CRISTINA;LANGA POZA, CARMEN;BLANCO LOPEZ, FRANCISCO JAVIER;LOPEZ NOVOA, JOSE MIGUEL |
分类号 |
C07K14/71;A61K38/17;A61P9/12 |
主分类号 |
C07K14/71 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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