Accelerated gelation of regenerated fibroin

摘要

The invention discloses a process for the acceleration of gelling time of regenerated silk fibroin using gelling agent, preferably silica to create a porous structure, devoid of microbial growth.

主权项

1. A process for gelation of regenerated silk fibroin (RSF) to obtain a gel having a porous structure comprising the steps of:
a) adjusting (i) the pH of a regenerated silk fibroin solution to pH 5-7.5 and (ii) its concentration to be in the range of 0.1 to 40 w/w %; b) adding a gelation agent selected from the group consisting of silica, FeO2SiN3 and hydroxyapetite, and maintaining temperature of a mixture of said silk fibroin solution and gelation agent at a range of 20-70° C. to obtain RSF gel; and c) Checking the gelation of RSF by tube inversion method or vial tilting method.