| 主权项 |
1. A tissue regeneration system comprising:
a porous template consisting of β-tricalcium phosphate and having thereupon at least one synthetic, degradable extracellular matrix layer; and at least one biomolecule releasably associated with the matrix layer, the biomolecule comprising a cell-affecting portion, wherein the cell-affecting portion is selected from the group consisting of growth factors selected from the group consisting of bone morphogenic protein, fibroblast growth factor, growth differentiation factor, platelet-derived growth factor, placental growth factor, transforming growth factor, insulin-like growth factor, vascular endothelial growth factor, bone sialoprotein, phosphoryn, osteonectin and combinations thereof, wherein the growth factor is capable of initiating at least one of osteogenesis, neovascularization, endothelial differentiation, and osteogenic differentiation, and fragments of growth factors selected from the group consisting of bone morphogenic protein, fibroblast growth factor, growth differentiation factor, platelet-derived growth factor, placental growth factor, transforming growth factor, insulin-like growth factor, vascular endothelial growth factor, bone sialoprotein, phosphoryn, osteonectin and combinations thereof, wherein the fragments are capable of initiating at least one of osteogenesis, neovascularization, endothelial differentiation, and osteogenic differentiation; and a matrix-binding portion, wherein the matrix-binding portion is selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, SEQ ID NO:15, SEQ ID NO:16, and SEQ ID NO:17. |
