| 发明名称 | USP47 inhibitors and methods to induce apoptosis | ||
| 摘要 | The present invention relates to USP47 (ubiquitin specific protease 47) inhibitors and methods for inducing apoptosis or cell death in a target cell. In certain embodiments, the invention relates to methods and kits to screen for related agents that induce apoptosis. Additionally, the invention relates to assays for screening compounds capable of acting as USP47 inhibitors. | ||
| 申请公布号 | US8778905(B2) | 申请公布日期 | 2014.07.15 |
| 申请号 | US201213668969 | 申请日期 | 2012.11.05 |
| 申请人 | New York University | 发明人 | Pagano Michele;Skaar Jeffrey R.;Peschiaroli Angelo;Dorrello N. Valerio |
| 分类号 | C12N15/11;A61K48/00;C07H21/02;C07H21/04;A61K38/00;A61P43/00 | 主分类号 | C12N15/11 |
| 代理机构 | Troutman Sanders LLP | 代理人 | Troutman Sanders LLP |
| 主权项 | 1. A method of inducing apoptosis or cell death comprising contacting a target cell with an effective amount of an inhibitor of ubiquitin specific protease 47 (USP47), wherein the inhibitor of USP47 is a siRNA or a small molecule, wherein said small molecule has a molecular weight of less than about 2000 Daltons. | ||
| 地址 | New York NY US | ||