Immunogenic compositions for gram positive bacteria such as <i>Streptococcus agalactiae </i>

摘要

The invention relates to the identification of a new adhesin islands within the genomes of several Group A and Group B Streptococcus serotypes and isolates. The adhesin islands are thought to encode surface proteins which are important in the bacteria's virulence. Thus, the adhesin island proteins of the invention may be used in immunogenic compositions for prophylactic or therapeutic immunization against GAS or GBS infection. For example, the invention may include an immunogenic composition comprising one or more of the discovered adhesin island proteins.

主权项

1. An immunogenic composition comprising:
a first and a second purified or isolated S. agalactiae (Group B Streptococcus; GBS) adhesin island (AI) polypeptide, wherein the first GBS AI polypeptide is a GBS80 protein comprising the amino acid sequence SEQ ID NO: 2 or an immunogenic fragment thereof and wherein the second GBS AI polypeptide is a GBS67 protein comprising the amino acid sequence SEQ ID NO: 16 or an immunogenic fragment thereof; and a pharmaceutically acceptable buffer.