| 发明名称 | Polyvalent chimeric OspC vaccinogen and diagnostic antigen | ||
| 摘要 | A chimeric polyvalent recombinant protein for use as a vaccine and diagnostic for Lyme disease is provided. The chimeric protein comprises epitopes of the loop 5 region and/or the alpha helix 5 region of outer surface protein C (OspC) types. The OspC types may be associated with mammalian Borrelia infections. | ||
| 申请公布号 | US8778352(B2) | 申请公布日期 | 2014.07.15 |
| 申请号 | US201012840653 | 申请日期 | 2010.07.21 |
| 申请人 | Virginia Commonwealth University | 发明人 | Marconi Richard Thomas;Earnhart Christopher |
| 分类号 | A61K39/00 | 主分类号 | A61K39/00 |
| 代理机构 | Whitham, Curtis, Christofferson & Cook, P.C. | 代理人 | Whitham, Curtis, Christofferson & Cook, P.C. |
| 主权项 | 1. A chimeric recombinant protein comprising a loop 5 region of Borrelia OspC protein corresponding to amino acid residues 1-29 as set forth in SEQ ID NO: 103, and an alpha helix 5 region of Borrelia OspC protein corresponding to amino acid residues 10-60 as set forth in SEQ ID NO: 119. | ||
| 地址 | Richmond VA US | ||