| 发明名称 | <i>Trypanosoma </i>antigens, vaccine compositions, and related methods | ||
| 摘要 | The present invention relates to the intersection of the fields of immunology and protein engineering, and particularly to antigens and vaccines useful in prevention of infection by Trypanosoma protozoa. Provided are recombinant protein antigens, compositions, and methods for the production and use of such antigens and vaccine compositions. | ||
| 申请公布号 | US8778348(B2) | 申请公布日期 | 2014.07.15 |
| 申请号 | US200812110877 | 申请日期 | 2008.04.28 |
| 申请人 | iBio Inc. | 发明人 | Knapp Elisabeth;Yusibov Vidadi |
| 分类号 | A61K39/00 | 主分类号 | A61K39/00 |
| 代理机构 | Fish & Richardson P.C. | 代理人 | Fish & Richardson P.C. |
| 主权项 | 1. An isolated antigen comprising a component of a Trypanosoma protein fused to alfalfa mosaic virus (AlMV) coat protein; wherein the Trypanosoma protein component is a fragment of alpha tubulin or a fragment of beta tubulin consisting of one or more amino acid sequences selected from the group consisting of SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, SEQ ID NO:16, SEQ ID NO:18, SEQ ID NO:19, and SEQ ID NO:20. | ||
| 地址 | Newark DE US | ||