Clickable cross-linker

摘要

A clickable cross-linker compound provides an easily scanned reporter ion for effective and efficient cross-linking and identification of intermolecular and intramolecular interactions of proteins and peptides.

主权项

1. A composition comprising a cross-linker compound represented by Formula I: wherein: each of M1 and M2 is a chemical moiety that conjugates to a functional group of a protein, a peptide, or a nucleic acid; each of L1 and L2 is independently a linkage comprising 1 to 20 carbon atoms or 1 to 6 polyethylene glycol groups; and R is a reporter group selected from the group consisting of hexynyl groups, pentynyl groups, heptynyl groups, azido-propyl groups, azido-butyl groups, and azido-pentyl groups.