| 主权项 |
1. A compound of the formula (I):wherein
W, X and Y are each independently CH, C(R4) or N; Z is C(R6); R1 and R2 are each independently hydrogen or C1-6 alkyl; or R1 and R2 taken together with the carbon atom to which they are attached may form a 5- or 6-membered carbocycle or heterocycle, either of which is optionally substituted with 1, 2, 3, 4 or 5 Ra; R3 and R4 are each independently halo or a group selected from C1-6 alkyl, C1-6 alkoxy, carbocyclyl and heterocyclyl, any of which is optionally substituted with 1, 2, 3, 4 or 5 Ra; wherein R5 and R6 taken together with the carbon atom to which they are attached form a 5- or 6-membered heterocycle containing a ring amide group, wherein the heterocycle is unsubstituted; each Ra is independently selected from halogen, trifluoromethyl, cyano, oxo, nitro, —ORb, —C(O)Rb, —C(O)ORb, —OC(O)Rb, —S(O)lRb, —N(Rb)Rc, —N(Rb)C(O)Rc, —C(O)N(Rb)Rc, —S(O)lN(Rb)Rc and Rd; Rb and Rc are each independently hydrogen or Rd; Rd is selected from hydrocarbyl (e.g. C1-6alkyl), carbocyclyl, carbocyclyl-C1-6alkyl, and heterocyclyl, each of which is optionally substituted with 1, 2, 3, 4 or 5 substituents independently selected from halogen, cyano, amino, hydroxy, C1-6 alkyl, C1-6 alkoxy; l is 0, 1 or 2; and m and n are each independently 1, 2 or 3;or a pharmaceutically acceptable salt or N-oxide thereof. |
