发明名称 Oligomer conjugates of heteropentacyclic nucleosides
摘要 The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer.
申请公布号 US8778898(B2) 申请公布日期 2014.07.15
申请号 US201313897116 申请日期 2013.05.17
申请人 Nektar Therapeutics 发明人 Deng Bo-Liang;Riley Timothy A.;Riggs-Sauthier Jennifer
分类号 A01N43/04;A61K31/70 主分类号 A01N43/04
代理机构 代理人 Marquart Timothy A.
主权项 1. A method of treating influenza, comprising administering to a patient, a compound having the following structure:wherein: R2 is hydrogen or hydroxyl; R3 is hydroxyl when R2 is hydrogen and R3 is hydrogen when R2 is hydroxyl; (a) is two; X is an amide linkage; and each POLY is independently a water-soluble, non-peptidic oligomer, and 5′-phosphates and 3′,5′-cyclic phosphates thereof and ammonium and alkali metal salts of each of the 5′-phosphates and 3′,5′-cyclic phosphates.
地址 San Francisco CA US