Vaccine for the treatment of <i>Mycobacterium </i>related disorders

摘要

The invention relates to genes and proteins involved in the sporulation of Mycobacteria and the use thereof in the technical fields of immunology and medicine. A vaccine comprising spore forming peptides, such as CotA or CotD, or antibodies thereto is used for the treatment of diseases caused by Mycobacterium such as leprosy and tuberculosis.

主权项

1. A method for detecting a spore related peptide from a Mycobacteria species in a sample, comprising determining the presence in said sample of a full-length spore related peptide selected from the group consisting of SEQ ID NO:2, 4, 6, 8, 10, 12, 16, 18, 20, 22, 24, 26, CotA, CotD, CotT, CotSA, SpoVK, SpoVE, Soj, SpoIIIE, and YrbC, or an immunogenic fragment thereof, from a Mycobacteria species selected from the group consisting of Mycobacterium marinum, Mycobacterium bovis, Mycobacterium tuberculosis, and Mycobacterium avium subspecies paratuberculosis by detecting the binding of said full-length spore related peptide, or said immunogenic fragment thereof, to a binding molecule specific for said full-length spore related peptide, or said immunogenic fragment thereof.