Artificial bone and joint compositions and methods of use and manufacture

摘要

The present invention provides a ceramic porous body for in-vitro and in-vivo use comprising a composition comprising a calcium aluminate (CA) containing phase and optionally at least one of an accelerator, a retarder, a surfactant, a foaming agent, a reactive alumina, water, a fiber, and a biologically active material, and combinations thereof. Ceramic compositions are provides as well as method of using the ceramic compositions and methods of manufacturing a ceramic porous body. The ceramic porous bodies of this invention may be used as artificial bones, joints, in-vitro support structures, and in-vivo support structures for cells, tissues, organs, and nerve growth and regeneration.

主权项

1. A porous ceramic composition consisting essentially of:
a calcium aluminate (CA) containing phase having the formula CnAy, wherein n is an integer from about 1 to about 12 and y is an integer from about 1 to about 24, said CA containing phase having at least a CaAl2O4 phase and a CaAl4O7 phase, including phosphate containing phases resulting from the interaction of CnAy, CnAy-hydrates wherein n is an integer from about 1 to about 12 and y is an integer from about 1 to about 24, CaO, AlnOy, and AlnOy-hydrates wherein n is an integer from about 1 to about 12 and y is an integer from about 1 to about 24 with PnOyx, wherein in the formula PnOy n is an integer 1, 2, or 3 and y is an integer 3, 4, or 7 and x is a negatively charged integer of 1, 3, or 4; and a biologically active material that comprises one or more proteins for promoting bone growth.