发明名称 |
COMPOSITION COMPRISING A DENDRIMER AND THE USE THEREOF FOR BINDING PHOSPHATE |
摘要 |
The present invention provides improved methods and compositions for therapeutically controlling and/or reducing serum phosphate levels in animals and mammalian patients. The methods comprise administering to the patient an amount of a dendrimer composition effective to prevent absorption of substantial amounts of phosphate from the patient's GI tract. In a preferred version, a dose of between 2.5 and 15 grams per day is effective to prevent over 80% of phosphate present in the patient's GI tract from being absorbed. The dendrimer composition may comprise a hydrochloride, hydrobromide, hydroacetate or hydroanionic form. |
申请公布号 |
CA2622021(C) |
申请公布日期 |
2014.07.15 |
申请号 |
CA20062622021 |
申请日期 |
2006.09.13 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
DELUCA, HECTOR F.;WILLIAMS, KATIE BETH;BARCYKA, KATARZYNA |
分类号 |
A61K31/785;A61K31/132;A61P3/12 |
主分类号 |
A61K31/785 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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